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Efficient Bayesian Regularization for Graphical Model Selection.

Suprateek Kundu1, Bani K Mallick2, Veera Baladandayuthapan3

  • 1Department of Biostatistics & Bioinformatics, Emory University, 1518 Clifton Road, Atlanta, Georgia 30322, U.S.A.

Bayesian Analysis
|October 30, 2020
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Summary
This summary is machine-generated.

We developed a new Bayesian graphical model for high-dimensional data, improving precision matrix selection. This method is computationally efficient and accurate for large datasets, outperforming existing approaches.

Keywords:
Cholesky-based regularizationcovariance selectionjoint penalized credible regionsselection consistencyshrinkage priors

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Area of Science:

  • Statistics
  • Machine Learning
  • Computational Biology

Background:

  • Bayesian graphical models are crucial for analyzing complex data structures.
  • Existing methods struggle with high-dimensional data where the number of variables exceeds sample size.
  • Scalability remains a challenge in Bayesian graphical model selection.

Purpose of the Study:

  • To introduce a novel Bayesian graphical model selection approach for large-dimensional settings.
  • To decouple model fitting and covariance selection for computational efficiency.
  • To provide theoretical guarantees for selection consistency.

Main Methods:

  • A full model is fitted using a novel class of mixtures of inverse-Wishart priors.
  • Priors induce shrinkage on the precision matrix, equivalent to Cholesky-based regularization.
  • Post-fitting model selection employs penalized joint credible regions.
  • Gibbs samplers and efficient post-fitting inferences ensure computational feasibility.

Main Results:

  • The proposed method demonstrates computational feasibility for large dimensions.
  • Theoretical guarantees for selection consistency are established.
  • Simulations show favorable comparisons with competing methods in accuracy and speed.
  • The approach was successfully applied to cancer genomics data.

Conclusions:

  • The novel Bayesian graphical model offers an effective solution for high-dimensional data.
  • The decoupling strategy enhances computational efficiency and scalability.
  • The method provides reliable model selection with theoretical backing.