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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
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Vascular calcification; Stony bridge between kidney and heart
Behzad Zaker1,2, Mohammadreza Ardalan1
1Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Journal of Cardiovascular and Thoracic Research
|October 30, 2020
Summary
Vascular calcification, common in cardiovascular patients due to mineral imbalance, involves various factors and vessel layers. Its exact mechanisms and pathways require further scientific investigation.
Area of Science:
- Cardiovascular Medicine
- Biochemistry
- Pathophysiology
Background:
- Vascular calcification is a prevalent complication in cardiovascular patients.
- It results from disruptions in calcium and phosphate homeostasis.
- Factors like molecular pathways, genetics, and lifestyle contribute to its development.
Purpose of the Study:
- To summarize the current understanding of vascular calcification.
- To highlight the complexity of its underlying mechanisms.
- To identify areas needing further research.
Main Methods:
- Review of existing literature on vascular calcification.
- Analysis of factors influencing mineral balance in cardiovascular disease.
- Classification of vascular calcification based on affected vessel layers.
Main Results:
- Vascular calcification is linked to impaired calcium and phosphate balance.
- Multiple molecular inducers, inhibitors, genetic factors, and lifestyle elements are implicated.
- Different types of vascular calcification occur depending on the involved vessel layer (intima, media, or both).
Conclusions:
- The precise mechanisms and consensus pathways of vascular calcification remain unclear.
- Further research is essential to fully elucidate the pathophysiology of vascular calcification.
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