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MicroRNA-24 in Cancer: A Double Side Medal With Opposite Properties

Sumei Wang1,2,3, Nayan Liu1,2,3,4, Qing Tang1,2,3

  • 1Department of Oncology, Clinical and Basic Research Team of Traditional Chinese Medicine Prevention and Treatment of Non-Small Cell Lung Cancer, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.

Frontiers in Oncology
|October 30, 2020
PubMed

Insights

MicroRNA-24 (miR-24) acts as both a tumor suppressor and oncogene in human cancers. This microRNA is crucial in cancer diagnosis, prognosis, and predicting treatment response, offering potential therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • MicroRNA-24 (miR-24) is implicated in various human cancers.
  • Its expression levels vary, suggesting complex roles in tumorigenesis.

Purpose of the Study:

  • To review the dual role of miR-24 in human cancers.
  • To explore miR-24's potential as a diagnostic, prognostic, and predictive biomarker.
  • To highlight miR-24 as a therapeutic target.

Main Methods:

  • Literature review of recent surveys on miR-24 in human cancers.
  • Analysis of miR-24's dysregulation and its clinical correlations.
  • Examination of miR-24's involvement in tumor initiation, progression, and therapy.

Main Results:

  • miR-24 exhibits down-regulation in some cancers (tumor suppressor) and up-regulation in others (oncogene).
  • Dysregulated miR-24 correlates with clinical performance and patient outcomes.
  • miR-24 influences tumor initiation, progression, and response to chemo- and radio-therapy.

Conclusions:

  • miR-24 plays a dual role in human cancer development and progression.
  • miR-24 serves as a potential non-invasive diagnostic marker.
  • miR-24 is a promising prognostic and predictive biomarker for cancer treatment and a potential therapeutic target.
Keywords:
biomarkercancerinitiationmiR-24progression

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