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The Role of Long Non-coding RNAs in Cancer Metabolism: A Concise Review

Soudeh Ghafouri-Fard1, Hamed Shoorei2, Mohammad Taheri3

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Frontiers in Oncology
|October 30, 2020
PubMed

Insights

Long non-coding RNAs (lncRNAs) significantly impact cancer metabolism by regulating key pathways like glucose, amino acid, and lipid homeostasis. These lncRNAs offer promising new targets for developing innovative cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Metabolic pathway dysregulation is a cancer hallmark, recognized over 60 years ago.
  • Gene expression alterations, including those in metabolic pathways, contribute to cancer pathogenesis.
  • Long non-coding RNAs (lncRNAs) have emerged as critical regulators of biological functions in the last decade.

Purpose of the Study:

  • To review the recent literature on the role of lncRNAs in cancer metabolism.
  • To highlight the significance of lncRNAs in developing novel cancer therapeutic strategies.

Main Methods:

  • Comprehensive literature review of studies investigating lncRNAs and cancer metabolism.
  • Analysis of lncRNA regulatory mechanisms in key metabolic pathways.
  • Evaluation of lncRNAs' role in mitochondrial function and potential as therapeutic targets.

Main Results:

  • lncRNAs regulate gene expression at multiple levels, influencing cancer-related pathways.
  • lncRNAs are implicated in the dysregulation of glucose, amino acid, and lipid metabolism in cancer.
  • lncRNAs play critical roles in regulating mitochondrial function, presenting them as potential therapeutic targets.

Conclusions:

  • lncRNAs are key players in cancer metabolism, affecting fundamental processes like energy homeostasis.
  • Targeting lncRNAs involved in cancer metabolism represents a promising avenue for novel therapeutic interventions.
  • Further research into lncRNA functions can accelerate the design of effective cancer treatments.
Keywords:
biomarkercancer metabolismexpressionlncRNAoncogene

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