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Long Non-coding RNAs Involved in Metabolic Alterations in Breast and Prostate Cancers

Shuhei Kamada1,2, Toshihiko Takeiwa1, Kazuhiro Ikeda1

  • 1Division of Systems Medicine and Gene Therapy, Saitama Medical University, Saitama, Japan.

Frontiers in Oncology
|October 30, 2020
PubMed

Insights

Long non-coding RNAs (lncRNAs) are key regulators of metabolism in hormone-dependent and -independent breast and prostate cancers. Understanding lncRNAs offers new avenues for cancer diagnosis and treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Metabolism

Background:

  • Breast and prostate cancers are prevalent, sex hormone-dependent malignancies.
  • Hormonal therapies are standard treatments, but resistance and initial hormone-independence pose challenges.
  • Understanding cancer pathophysiology is crucial for developing new therapeutic strategies.

Purpose of the Study:

  • To review the role of long non-coding RNAs (lncRNAs) in cancer metabolism.
  • To focus on lncRNAs involved in both sex hormone-dependent and -independent pathways in breast and prostate cancers.
  • To highlight the potential of lncRNAs in cancer diagnosis and treatment.

Main Methods:

  • Literature review of recent studies on lncRNAs, metabolism, and sex hormone-related cancers.
  • Analysis of mechanisms by which lncRNAs modulate metabolic reprogramming.
  • Focus on signaling pathways and regulators involved in cancer metabolism.

Main Results:

  • Metabolic reprogramming, including alterations in glucose, oxidative phosphorylation, and lipid metabolism, is a hallmark of cancer.
  • Dysregulation of metabolic enzymes and signaling molecules contributes to cancer-specific metabolic alterations.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their role in regulating cancer metabolism and progression.

Conclusions:

  • lncRNAs play a significant role in the metabolic alterations observed in breast and prostate cancers.
  • Targeting lncRNAs involved in cancer metabolism may offer novel therapeutic strategies.
  • Further research into lncRNA-metabolism interactions is essential for advancing cancer treatment.
Keywords:
breast cancercancer metabolismglucoselipidlong non-coding RNAoxidative phosphorylationprostate cancer

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