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Updated: Dec 3, 2025

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Multiple Uveal Melanoma.

Wajiha J Kheir¹, Jane S Kim¹, Miguel Angel Materin¹

¹Duke Eye Center, Duke University School of Medicine, Durham, North Carolina, USA.

Ocular Oncology and Pathology

|October 30, 2020

Summary

This summary is machine-generated.

Multiple uveal melanomas, though rare, can occur as bilateral or multifocal tumors. Regular eye examinations are vital for detecting new tumors or metastases, ensuring timely treatment.

Keywords:

BAP1 BRCA2 Bilateral choroidal/uveal melanoma Contralateral metastasis Interocular metastasis Intraocular metastasis Oculodermal melanocytosis Unilateral multifocal choroidal/uveal melanoma Unilateral multiple choroidal/uveal melanoma

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Area of Science:

Ophthalmology
Oncology
Medical Genetics

Background:

Multiple uveal melanoma is a rare condition, encompassing bilateral, unilateral multifocal, or metastatic disease to either eye.
Understanding the presentation and management of multiple uveal melanoma is crucial due to its rarity.

Purpose of the Study:

To investigate the occurrence and characteristics of multiple uveal melanoma.
To highlight the importance of regular follow-up for early detection of new primary tumors or metastases.

Main Methods:

A retrospective chart review was conducted for patients diagnosed with uveal melanoma between January 2013 and January 2019.
Duke University Eye Center Ophthalmic Oncology Service data was analyzed.

Main Results:

Five patients with multiple uveal melanomas were identified, including bilateral choroidal melanoma and multiple melanomas within the same eye.
Treatments included I-125 radioactive plaque brachytherapy (PBT) and PBRT. Two patients presented with metastatic uveal melanoma.
Genetic testing revealed no BAP1 mutations in two patients, with one having a BRCA2 variant. Oculodermal melanocytosis was noted in one patient.

Conclusions:

Multiple uveal melanoma, while uncommon, necessitates vigilant monitoring.
Regular examinations of both the treated and contralateral eyes are essential for identifying local recurrence, new metastases, and additional primary tumors.