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Related Experiment Video

Updated: Dec 3, 2025

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality
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Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality

Published on: October 18, 2024

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Short-term application of ibuprofen before ovulation.

A S Kohl Schwartz1, S Burkard1, V R Mitter1

  • 1University Women's Hospital, Division of Gynecological Endocrinology and Reproductive Medicine, Inselspital, Bern University Hospital, Bern, Switzerland.

Facts, Views & Vision in Obgyn
|October 30, 2020
PubMed
Summary
This summary is machine-generated.

Ibuprofen, a non-selective cyclooxygenase (COX) inhibitor, does not appear to harm oocyte competence or embryo quality in women undergoing natural cycle in vitro fertilization (IVF). This finding suggests ibuprofen is safe for pain relief around ovulation in fertility treatments.

Keywords:
IVFIboprufenimplantation ratenatural cycle IVFnon-steroidal anti-inflammatory drugovulation

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Area of Science:

  • Reproductive endocrinology and fertility research.
  • Pharmacology of non-steroidal anti-inflammatory drugs (NSAIDs).

Background:

  • Selective cyclooxygenase (COX) inhibitors have demonstrated negative impacts on female fertility.
  • Limited data exists on the effects of non-selective COX inhibitors, like ibuprofen, on fertility, leading to cautious recommendations for women trying to conceive.
  • Ibuprofen is a widely used over-the-counter analgesic.

Purpose of the Study:

  • To investigate the potential negative effects of ibuprofen on oocyte competence and embryo quality.
  • To evaluate the safety of ibuprofen use around ovulation in the context of natural cycle in vitro fertilization (IVF).

Main Methods:

  • Observational study comparing ibuprofen-exposed and unexposed women (18-42 years) undergoing natural cycle IVF.
  • Monitoring follicular growth and triggering ovulation; ibuprofen administered to women with luteinizing hormone (LH) surge to postpone ovulation.
  • Analysis of oocyte retrieval rate, oocyte maturity, fertilization rate, embryo development, embryo quality, and implantation rate.

Main Results:

  • No significant differences were observed in the rates of mature oocytes or implantation between the ibuprofen and control groups.
  • Logistic regression analysis revealed no significant association between ibuprofen intake, LH levels, or infertility reasons and embryo quality.

Conclusions:

  • Ibuprofen use around ovulation does not appear to negatively impact oocyte competence or embryo quality in natural cycle IVF.
  • The findings suggest that ibuprofen can be safely used as an analgesic treatment in this specific patient population.