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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Related Experiment Video

Updated: Jul 16, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Monosodium L-glutamate-induced asthma.

D H Allen1, J Delohery, G Baker

  • 1Department of Thoracic Medicine, Royal North Shore Hospital, Sydney, Australia.

The Journal of Allergy and Clinical Immunology
|October 1, 1987
PubMed
Summary

Monosodium L-glutamate (MSG) can trigger asthma in sensitive individuals. Reactions vary, with some experiencing immediate symptoms and others delayed, making MSG a potential asthma trigger.

Area of Science:

  • Allergy and Immunology
  • Pulmonology
  • Gastroenterology

Background:

  • Asthma exacerbations are increasingly linked to ingested substances like aspirin and sulfites.
  • The role of monosodium L-glutamate (MSG), a common food additive, as an asthma trigger is under investigation.

Observation:

  • 32 individuals with asthma, some with a history of reactions to spiced meals, participated in the study.
  • Subjects underwent a single-blind, placebo-controlled challenge with escalating doses of MSG (0.5 gm to 5.0 gm) after a 5-day additive-free diet.

Findings:

  • Thirteen subjects (40.6%) reacted to MSG.
  • Seven subjects experienced immediate asthma and "Chinese restaurant syndrome" symptoms (1-2 hours post-ingestion).
  • Six subjects had delayed asthma onset (6-12 hours post-ingestion) without "Chinese restaurant syndrome" symptoms.

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Implications:

  • MSG is confirmed as a potential asthma-provoking agent.
  • MSG-induced asthma reactions are dose-dependent and can be delayed, complicating diagnosis.
  • Physicians and patients should consider MSG as a potential trigger in unexplained asthma cases.