Related Experiment Video

Updated: Dec 3, 2025

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
05:28

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

4.1K

Evaluation of Sepsis-Induced Coagulopathy in Critically Ill Pediatric Patients with Septic Shock

Won Kyoung Jhang1, Seong Jong Park1

  • 1Division of Pediatric Critical Care Medicine, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea.

Thrombosis and Haemostasis
|October 30, 2020
PubMed

Insights

A modified sepsis-induced coagulopathy (SIC) score accurately predicts mortality in critically ill children with septic shock. This new score, incorporating the pediatric sequential organ failure assessment (pSOFA), prothrombin time, and D-dimer, offers improved prognostic value.

Area of Science:

  • Pediatric critical care medicine
  • Hematology
  • Infectious diseases

Background:

  • Coagulopathy is a frequent and severe complication in pediatric sepsis and septic shock.
  • Early detection and management of coagulopathy are crucial for improving patient outcomes.
  • The sepsis-induced coagulopathy (SIC) score was recently developed for adult patients.

Purpose of the Study:

  • To modify the SIC score for critically ill children with septic shock.
  • To evaluate the performance of the modified SIC score in diagnosing coagulopathy.
  • To assess the modified SIC score's ability to predict 28-day mortality in this population.

Main Methods:

  • A modified SIC score was developed using the pediatric sequential organ failure assessment (pSOFA) score, prothrombin time, and D-dimer.
  • The modified SIC score was applied to 135 critically ill children with septic shock.
  • The modified SIC score's performance was compared to existing coagulopathy scoring systems, including the SIC and ISTH DIC scores.

Main Results:

  • Coagulopathy was diagnosed in a significant proportion of patients (up to 84.4% by SIC score).
  • The modified SIC score correlated well with pSOFA, ISTH DIC, and SIC scores (p < 0.001).
  • The modified SIC score demonstrated good predictive performance for 28-day mortality (AUC = 0.771), outperforming SIC and ISTH DIC scores (p < 0.05).

Conclusions:

  • Critically ill pediatric patients with septic shock often present with coagulopathy.
  • The modified SIC score is a reliable tool for diagnosing coagulopathy in this cohort.
  • The modified SIC score shows potential as an independent prognostic factor for 28-day mortality in pediatric septic shock.
Abstract

More Related Videos

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock09:09

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

Published on: November 3, 2023

1.3K
Cecal Ligation Puncture Procedure11:53

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

55.9K

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
167
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
141
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
150
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
506
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
122