Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Soft tissue reaction to ceramic ossicular replacement prosthesis.

E Yamamoto1, M Iwanaga

  • 1Department of Otolaryngology, Faculty of Medicine, Kyoto University, Japan.

The Journal of Laryngology and Otology
|September 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-Reconstruction of Order Parameter in Spin-Triplet Superconductor UTe_{2}.

Physical review letters·2025
Same author

Effect of uranium deficiency on normal and superconducting properties in unconventional superconductor UTe<sub>2</sub>.

Journal of physics. Condensed matter : an Institute of Physics journal·2022
Same author

Erratum: Azimuthal Anisotropy of K_{S}^{0} and Λ+Λ[over ¯] Production at Midrapidity from Au+Au Collisions at sqrt[s]_{NN}=130  GeV [Phys. Rev. Lett. 89, 132301 (2002)].

Physical review letters·2021
Same author

Erratum: Azimuthal Anisotropy at the Relativistic Heavy Ion Collider: The First and Fourth Harmonics [Phys. Rev. Lett. 92, 062301 (2004)].

Physical review letters·2021
Same author

Efficiency of genomic selection for breeding population design and phenotype prediction in tomato.

Heredity·2016
Same author

Direct observation of lattice symmetry breaking at the hidden-order transition in URu2Si2.

Nature communications·2014

Ceramic ossicular replacement prostheses (CORP) show excellent soft-tissue compatibility. Histological evaluation revealed minimal inflammation after three months, supporting their clinical success in middle ear surgery.

Area of Science:

  • Otolaryngology
  • Biomaterials Science
  • Histopathology

Background:

  • Ceramic ossicular replacement prostheses (CORP) are used in middle ear reconstructive surgery.
  • Understanding the soft-tissue response to implanted biomaterials is crucial for surgical outcomes.
  • Previous assessments of CORP soft-tissue reaction have been limited.

Purpose of the Study:

  • To histologically evaluate the soft-tissue reaction to ceramic ossicular replacement prostheses (CORP) in animal and human subjects.
  • To correlate histological findings with clinical outcomes of CORP implantation.

Main Methods:

  • Histological examination of tissue surrounding CORP implants in rabbits and humans at one week, one month, and three months post-implantation.
  • Assessment of inflammatory cell infiltration, foreign body reaction, and fibrous encapsulation.

Related Experiment Videos

Main Results:

  • A severe inflammatory and foreign body reaction was observed around the CORP one week after implantation.
  • By three months post-implantation, the CORP was encapsulated by fibrous connective tissue with minimal to no inflammatory cells or foreign body giant cells.
  • Absence of significant inflammatory response at three months indicates good biocompatibility.

Conclusions:

  • Ceramic ossicular replacement prostheses (CORP) demonstrate excellent soft-tissue compatibility.
  • The minimal inflammatory response observed supports the satisfactory clinical results achieved with CORP in ossiculoplasty without cartilage interposition.