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Massive metoprolol ingestion associated with a fatality--a case report
C D Riker1, R K Wright, W Matusiak
1Broward County Medical Examiner's Office, Fort Lauderdale, FL.
Journal of Forensic Sciences
|September 1, 1987
Summary
A 26-year-old male died after intentionally ingesting 10g of metoprolol. Autopsy revealed coronary artery thrombosis and early myocardial infarction, highlighting the dangers of metoprolol overdose.
Area of Science:
- Toxicology
- Cardiovascular Pathology
- Forensic Medicine
Background:
- Metoprolol is a commonly prescribed beta-blocker for cardiovascular conditions.
- Information on metoprolol intoxication, especially fatal cases, is limited in published literature.
Observation:
- A 26-year-old male intentionally ingested a large dose (approximately 10g) of metoprolol.
- Autopsy revealed foreign material in gastric contents.
- Acute thrombosis of the left anterior descending coronary artery was observed.
Findings:
- Microscopic examination indicated an extremely early myocardial infarct.
- Quantification of metoprolol concentrations in blood, liver, gastric content, and urine was performed using gas chromatography and spectrophotometry.
- Literature review confirmed scarcity of data on metoprolol intoxication.
Implications:
- This case underscores the potential for severe cardiovascular complications, including fatal thrombosis and infarction, following massive metoprolol overdose.
- Accurate toxicological analysis is crucial for diagnosing and managing metoprolol poisoning.
- Further research is warranted to understand the pathophysiology of metoprolol-induced cardiovascular events.