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Heparin-binding epidermal growth factor (EGF)-like growth factor in pediatric patients with type 1 diabetes mellitus

Dragana Kacarevic1, Natasa Bogavac-Stanojevic1, Vesna Spasojevic-Kalimanovska1

  • 1Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.

Growth Factors (Chur, Switzerland)
|October 30, 2020
PubMed

Insights

Increased levels of Heparin-binding EGF-like growth factor (HB-EGF) in children with type 1 diabetes mellitus are linked to oxidative stress and inflammation. These factors, including oxidized LDL, predict higher HB-EGF, suggesting a complex interplay.

Area of Science:

  • Biochemistry
  • Cardiovascular Disease
  • Pediatric Endocrinology

Background:

  • Heparin-binding EGF-like growth factor (HB-EGF) plays a role in atherosclerosis.
  • Type 1 diabetes mellitus (T1DM) is associated with increased cardiovascular risk.
  • Understanding biomarkers in T1DM is crucial for managing long-term complications.

Purpose of the Study:

  • To investigate the association between plasma HB-EGF levels and biomarkers of lipids, oxidative stress, and inflammation in pediatric patients with T1DM.
  • To identify predictors of elevated HB-EGF in this population.

Main Methods:

  • Plasma HB-EGF, hsCRP, PAB, TAS, oxLDL, and PON1 activity were measured in 74 T1DM patients and 40 controls.
  • Serum lipid parameters and metabolic control were also assessed.
  • Statistical analyses were performed to determine associations and predictors.

Main Results:

  • T1DM patients exhibited significantly higher HB-EGF, hsCRP, PAB, and oxLDL levels compared to controls (p < 0.01).
  • Patients also showed lower TAS and PON1 activity.
  • HB-EGF levels positively correlated with hsCRP, PAB, and oxLDL; hsCRP and oxLDL were independent predictors of HB-EGF.

Conclusions:

  • Oxidative modifications of LDL particles and low-grade inflammation are key determinants of elevated plasma HB-EGF in pediatric T1DM.
  • This highlights an interactive role between oxidative stress, dyslipidemia, and inflammation in T1DM pathophysiology.

Keywords:
HB-EGFhsCRPoxLDLoxidative stressparaoxonase 1

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