Related Experiment Video

Updated: Dec 3, 2025

Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence
08:05

Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence

Published on: June 10, 2025

941

Role of RASA1 in cancer: A review and update (Review)

Yanhua Zhang1, Yue Li1, Quanyue Wang2

  • 1Department of Oncology, First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434023, P.R. China.

Oncology Reports
|October 30, 2020
PubMed

Insights

Ras p21 protein activator 1 (RASA1) regulates cell processes and is implicated in tumor formation. This review explores RASA1

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Ras p21 protein activator 1 (RASA1) is a key regulator of Ras signaling pathways.
  • RASA1 plays a crucial role in physiological processes including angiogenesis, cell proliferation, and apoptosis.
  • Dysregulation of RASA1 is linked to pathological conditions such as vascular diseases and tumor development.

Purpose of the Study:

  • To review the multifaceted role of RASA1 in various cancer types.
  • To elucidate the molecular mechanisms and signaling pathways influenced by RASA1 in tumorigenesis.
  • To explore the potential of targeting RASA1 and its regulatory miRNAs for cancer therapy.

Main Methods:

  • Literature review of studies investigating RASA1 function in cancer.
  • Analysis of RASA1's involvement in Ras/RAF/MEK/ERK and Ras/PI3K/AKT signaling pathways.
  • Examination of miRNA-mediated regulation of RASA1 in tumor contexts.

Main Results:

  • RASA1 is implicated in the development and progression of lung, intestinal, liver, and breast tumors.
  • RASA1 influences tumor growth and survival through modulation of key oncogenic signaling cascades.
  • MicroRNAs (miRNAs) demonstrate regulatory control over RASA1 expression and function in cancer.

Conclusions:

  • RASA1 is a significant factor in the pathogenesis of diverse tumors.
  • Understanding RASA1's downstream signaling is critical for cancer research.
  • miRNA-based targeting of RASA1 presents a promising avenue for novel cancer therapeutics.
Keywords:
tumourRas p21 protein activator 1microRNAtherapy

More Related Videos

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

6.8K
Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

7.4K

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.8K
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
6.8K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.5K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.2K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.9K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.4K