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Related Experiment Videos

Calcium antagonists in hypertension.

F R Bühler1, W Kiowski

  • 1Department of Medicine, University Hospital, Basel, Switzerland.

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
|August 1, 1987
PubMed
Summary

Calcium antagonists effectively treat hypertension by relaxing arteries without affecting sympathetic activity. These calcium channel blockers are a valuable option for various patient groups and hypertensive emergencies.

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Area of Science:

  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Hypertension involves enhanced vasoconstriction due to altered smooth-muscle cation handling and increased intracellular calcium.
  • Calcium antagonists are arterial vasodilators with a favorable hemodynamic profile.

Purpose of the Study:

  • To evaluate the efficacy and suitability of calcium antagonists as monotherapy for hypertension.
  • To assess their role in managing uncomplicated, severe, and emergency hypertension.

Main Methods:

  • Review of clinical studies on calcium antagonists in hypertension treatment.
  • Analysis of hemodynamic effects, including sympathetic activity, sodium/volume retention, and arterial vasodilation.

Main Results:

  • Calcium antagonists demonstrate efficacy, safety, and acceptability in hypertension monotherapy and combination therapy.

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  • They are particularly effective in older patients, individuals with low renin levels, and Black patients.
  • These agents are also effective in severe, accelerated hypertension, and hypertensive emergencies.

    • Conclusions:

    • Calcium antagonists offer a valuable therapeutic option for hypertension due to their vasodilatory properties and lack of adverse hemodynamic effects.
    • Their efficacy across different patient populations and hypertensive conditions supports their role in managing this condition.