Related Experiment Video
Updated: Dec 3, 2025
07:10
A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT
Published on: June 12, 2020
5.4K
Anatomical variations in cortical bone surface permeability: Tibia versus femur.
Rakesh Kumar1, Abhishek Kumar Tiwari2, Dharmendra Tripathi3
1Department of Mechanical Engineering, Manipal University Jaipur, Jaipur, 303007, Rajasthan, India.
Journal of the Mechanical Behavior of Biomedical Materials
|October 30, 2020
Summary
Bone surfaces respond differently to mechanical loading, impacting new bone formation. This study measured bone permeability, finding endosteal bone more permeable than periosteal bone, crucial for predicting bone growth.
Area of Science:
- Biomaterials Science
- Biomechanics
- Orthopedic Research
Background:
- Cortical bone surfaces (periosteal and endosteal) show varied responses to mechanical loading, complicating in silico modeling of bone formation.
- Mechanical loading stimulates fluid flow within the bone's lacunar-canalicular system (LCS), which is believed to be osteogenic.
- Understanding micro-architectural properties like permeability is vital for predicting fluid flow and subsequent bone response.
Purpose of the Study:
- To quantify micro-architectural properties, specifically permeability, at different anatomical locations of periosteal and endosteal bone surfaces.
- To investigate variations in permeability between the periosteal and endosteal surfaces and between weight-bearing bones (tibia and femur).
- To provide data essential for developing accurate in silico models that predict site-specific bone formation based on fluid flow.
Main Methods:
- Employed nanoindentation to measure micro-architectural properties, including permeability, shear modulus, and Poisson's ratio.
- Utilized a standard poroelastic optimization technique to estimate these material properties.
- Compared properties across medial, lateral, anterior, and posterior anatomical locations on both periosteal and endosteal surfaces of tibia and femur.
Main Results:
- The endosteal bone surface demonstrated significantly higher permeability compared to the periosteal surface.
- Tibial endosteal surfaces exhibited greater permeability values than femoral endosteal surfaces across most anatomical locations.
- Significant differences in micro-architectural properties were observed between different anatomical sites and bone surfaces.
Conclusions:
- Permeability is a critical, yet underreported, micro-architectural property influencing fluid distribution and differential bone remodeling.
- The findings provide crucial data for refining computational models to predict site-specific osteogenesis.
- This research can inform the design of mechanical loading parameters to optimize bone healing and prevent bone loss.
Related Concept Videos
01:16Bones of the Lower Limb: Femur and Patella
4.5K
The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the...
4.5K
01:17Gross Anatomy of Bone
8.3K
The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in...
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in...
8.3K
01:09Spongy Bone
7.1K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
7.1K
01:10Bones of the Lower Limb: Tibia and Fibula
7.7K
The tibia is the main weight-bearing bone of the lower leg. It is larger than the fibula with which it is paired. The tibia is also the second longest bone in the body and is located right below the skin. The proximal end of the tibia forms the medial and the lateral condyle, which articulates with the condyles of the femur to form the knee joint. Between the articulating surfaces is the irregular elevated area known as the intercondylar eminence that serves as the inferior attachment point for...
7.7K
01:26Bone Markings
7.6K
Bones have various surface features that help form joints and attach to other soft tissues. Depending on the function, bone markings are categorized into articulating projections, processes for attachment, depressions, and openings.
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
7.6K
01:27Compact Bone
15.3K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
15.3K