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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
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Changes in physiology and immune system during pregnancy and coronavirus infection: A review

Miaomiao Chen1, Jing Zeng2, Xiyao Liu2

  • 1Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, China; Maternal and Child Health Hospital of Hubei Province, No. 745 Wuluo Road, Hongshan District, Wuhan City, Hubei Province, 430070, China.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|October 30, 2020
PubMed

Insights

Pregnant women face higher risks from COVID-19 due to physiological changes. This study explores their susceptibility to coronaviruses and links maternal symptoms to perinatal outcomes.

Area of Science:

  • Virology and Immunology
  • Maternal-Fetal Medicine
  • Epidemiology

Background:

  • The emergence of SARS-CoV-2, causing COVID-19, presents a global health challenge.
  • Pregnant women are identified as a high-risk group for coronavirus infections.
  • Previous coronaviruses include SARS-CoV and MERS-CoV, with significant public health impact.

Purpose of the Study:

  • To elucidate the reasons behind increased coronavirus susceptibility in pregnant women.
  • To analyze the relationship between maternal clinical symptoms and coronavirus infection.
  • To describe the impact of maternal coronavirus infection on perinatal outcomes.

Main Methods:

  • Review of physiological and immunological adaptations during pregnancy.
  • Analysis of clinical data correlating maternal symptoms with infection status.
  • Examination of perinatal outcomes in relation to maternal coronavirus infections.

Main Results:

  • Pregnancy-induced physiological and immune system changes contribute to heightened susceptibility.
  • Specific maternal clinical symptoms are associated with coronavirus infection.
  • Coronavirus infections in pregnant women show correlations with adverse perinatal outcomes.

Conclusions:

  • Understanding pregnancy-specific vulnerabilities is crucial for managing coronavirus infections.
  • Monitoring maternal symptoms aids in early detection and intervention.
  • The findings highlight the importance of protecting pregnant women and their fetuses from viral threats.

Keywords:
CoronavirusImmuneObstetric adverse outcomePhysiologyPregnancy

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