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Published on: October 25, 2015
Comparative transcriptome of reproductive axis in Chinese indigenous sheep with different FecB genotypes and
Dehong Tian1, Sijia Liu1, Fei Tian2
1Key Laboratory of Adaptation and Evolution of Plateau Biota, Qinghai Provincial Key Laboratory of Animal Ecological Genomics, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, Qinghai, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Abstract:
In the present study, there were 128, 263, and 139 differentially expressed genes (DEGs) from the ovary, pituitary, and hypothalamus, respectively, with the FecB B+/FecB ++ genotype. Results indicated that there was a synchronized, and differential increase in mRNA transcript abundances for genes encoding for ovarian steroidogenesis-signaling proteins in the ovary, TGF-β-signaling in hypothalamus, cAMP-signaling-transduction, and dopaminergic-synapse pathways in the pituitary. The values for these variables were associated with mean prolificacy in indigenous sheep and results provided indications for candidate regulator proteins that coordinate processes related to prolificacy in ewes. Furthermore, the results when there was evaluation of the FecB-genotype-specific co-expression modules implied that CYP17 was the hub gene connecting the pathways and for modulation of folliculogenesis and ovulation in the ewe with the FecB B+ genotype.
