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Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
Published on: August 23, 2016
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Zika Virus
Sophie Masmejan1, Didier Musso2,3, Manon Vouga1
1Maternofetal and Obstetrics Research Unit, Department "Woman-Mother-Child", University Hospital, 1011 Lausanne, Switzerland.
Pathogens (Basel, Switzerland)
|October 31, 2020
Summary
Zika virus (ZIKV) causes congenital infections and neurological issues. This review covers ZIKV epidemiology, transmission, and clinical concerns, highlighting challenges in treatment and prevention.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Zika virus (ZIKV) is a neurotropic flavivirus transmitted by *Aedes* mosquitoes.
- ZIKV outbreaks have impacted Africa, Southeast Asia, the Pacific, the Americas, and the Caribbean.
- Autochthonous transmission indicates ZIKV's potential to spread in Europe.
Purpose of the Study:
- To review the evolving epidemiology of ZIKV.
- To discuss ZIKV transmission modes and host-virus interactions.
- To outline clinical manifestations, diagnostic challenges, and concerns during pregnancy.
Main Methods:
- Literature review focusing on ZIKV epidemiology and pathogenesis.
- Analysis of clinical manifestations and diagnostic cross-reactivity.
- Examination of current treatment and prevention strategies.
Main Results:
- ZIKV poses significant risks for congenital infections and neurological disorders like microcephaly and Guillain-Barré syndrome.
- The virus has demonstrated a broad geographic reach and potential for adaptation.
- Diagnostic challenges exist due to cross-reactivity with other flaviviruses like dengue.
Conclusions:
- Understanding ZIKV's epidemiology and transmission is crucial for public health.
- Addressing diagnostic complexities and pregnancy-related concerns is vital.
- Overcoming challenges in ZIKV treatment and prevention requires continued research and intervention.
