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YAP/TAZ Signalling in Colorectal Cancer: Lessons from Consensus Molecular Subtypes
Sophie Mouillet-Richard1, Pierre Laurent-Puig1,2
1Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, F-75006 Paris, France.
This review explores the role of YAP/TAZ in colorectal cancer subtypes, highlighting knowledge gaps and future research directions for targeted therapies.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Colorectal cancer (CRC) heterogeneity is classified into four Consensus Molecular Subtypes (CMS).
- Each CMS subtype exhibits distinct molecular and clinical characteristics.
- Understanding signaling pathways driving CRC progression within CMS subtypes is crucial for developing targeted therapies.
Purpose of the Study:
- To review the involvement of YAP and TAZ, key Hippo pathway effectors, in colorectal cancer.
- To analyze YAP/TAZ roles specifically within the context of the CMS classification framework.
- To identify current knowledge gaps and propose future research directions.
Main Methods:
- Literature review focusing on YAP/TAZ function in colorectal cancer.
- Analysis of existing studies through the lens of the CMS classification.
- Synthesis of current understanding and identification of research needs.
Main Results:
- YAP and TAZ are significantly implicated in colon carcinogenesis.
- Their specific roles and implications may vary across different CMS subtypes.
- Current understanding of YAP/TAZ in CRC is fragmented concerning the CMS framework.
Conclusions:
- A comprehensive understanding of YAP/TAZ in CRC requires a CMS-specific perspective.
- Further research is needed to elucidate subtype-specific YAP/TAZ functions.
- Targeting YAP/TAZ pathways may offer subtype-specific therapeutic opportunities in colorectal cancer.
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