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Coagulation Parameters: An Efficient Measure for Predicting the Prognosis and Clinical Management of Patients with

Manuel Quintana-Díaz1, Eva María Andrés-Esteban2, Karen Lizzette Ramírez-Cervantes2

  • 1Intensive Care Unit, La Paz University Hospital, Research Group BPM, Idi-Paz Research Institute, Paseo de la Castellana, 261, 28046 Madrid, Spain.

Journal of Clinical Medicine
|October 31, 2020
PubMed

Insights

Coagulation abnormalities in COVID-19 patients, including lower prothrombin activity and higher D-dimer and fibrinogen levels, are linked to poorer prognosis. Monitoring these markers can aid in predicting outcomes and managing patients effectively.

Area of Science:

  • Medical research
  • Infectious diseases
  • Hematology

Background:

  • COVID-19 is a global pandemic affecting millions.
  • Coagulation abnormalities are frequently observed in COVID-19 patients.
  • Prognostic implications of these abnormalities require further investigation.

Purpose of the Study:

  • To evaluate the relationship between coagulation abnormalities and prognosis in COVID-19 patients.
  • To identify specific coagulation markers associated with patient outcomes.

Main Methods:

  • Retrospective cohort study of 3581 patients with COVID-19.
  • Data collected from Hospital La Paz, Madrid, Spain.
  • Analysis of coagulation parameters including prothrombin activity, fibrinogen, and D-dimer levels.

Main Results:

  • Non-survivors exhibited significantly lower prothrombin activity compared to survivors.
  • Non-survivors had higher levels of fibrinogen and D-dimer than survivors.
  • These differences in coagulation markers were statistically significant (p < 0.001).

Conclusions:

  • Coagulation parameters are potential indicators of prognosis in COVID-19.
  • Monitoring coagulation status can improve clinical management strategies.
  • Early identification of coagulation abnormalities may lead to better patient outcomes.
Abstract

Keywords:
COVID-19SARS-CoV-2coagulationcoronavirus

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