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Updated: Dec 3, 2025
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Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
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OCT ANGIOGRAPHY AND DOPPLER SONOGRAPHY IN NORMAL-TENSION GLAUCOMA
Summary
Visual field changes in normotensive glaucoma (NTG) are primarily linked to blood vessel density (VD) in the ophthalmic artery, not blood flow velocity. This finding highlights VD as a key factor in NTG progression.
Area of Science:
- Ophthalmology
- Neuroscience
- Medical Imaging
Background:
- Normotensive glaucoma (NTG) is a form of glaucoma where intraocular pressure is within the normal range.
- Understanding the pathophysiology of NTG is crucial for early diagnosis and effective management.
- Ocular blood flow, including vessel density and velocity, is increasingly recognized as a significant factor in glaucoma.
Purpose of the Study:
- To investigate the relationship between blood vessel density (VD) and blood flow velocity parameters in the ophthalmic artery (AO) and arteria centralis retinae (ACR).
- To determine the dependence of these vascular parameters on visual field (VF) changes in patients with normotensive glaucoma (NTG).
Main Methods:
- Employed Doppler sonography to assess peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index (RI) in the AO and ACR.
- Utilized optical coherence tomography (OCT) to evaluate vessel density (VD) in various ocular regions.
- Correlated vascular parameters with visual field sensitivity data obtained from automated perimetry in 20 NTG patients.
Main Results:
- Visual field changes in NTG patients were predominantly associated with peripapillary vessel density (VD) and VD across the entire measured area.
- A moderate negative correlation was observed between PSV in the AO and peripapillary VD, as well as overall VD.
- End diastolic velocity (EDV) in the AO showed a moderate negative correlation with VD in the whole area; other correlations were insignificant.
Conclusions:
- Blood vessel density (VD) in the ophthalmic artery is a more significant factor than perfusion parameters in driving visual field changes in NTG.
- Perfusion parameters within the arteria centralis retinae (ACR) did not show a significant correlation with visual field alterations in NTG patients.
- These findings suggest that VD assessment in the AO may be a valuable biomarker for monitoring NTG progression.
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