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Related Concept Videos

Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Dec 3, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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OPTIC CHIASM WIDTH IN NORMAL-TENSION AND HIGH-TENSION GLAUCOMA.

J Lešták, M Kyncl, M Fůs

    Ceska a Slovenska Oftalmologie : Casopis Ceske Oftalmologicke Spolecnosti a Slovenske Oftalmologicke Spolecnosti
    |October 31, 2020
    PubMed
    Summary

    Chiasm width reduces in both hypertensive glaucoma (HTG) and normotensive glaucoma (NTG) patients. This reduction correlates differently with visual field changes, suggesting distinct diagnostic pathways for HTG and NTG.

    Keywords:
    Hypertensive glaucomaMRIchanges in visual fieldnormotensive glaucomaoptic chiasm width

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    Area of Science:

    • Ophthalmology
    • Neuroscience

    Background:

    • Glaucoma, a leading cause of blindness, affects optic nerve health.
    • Hypertensive glaucoma (HTG) and normotensive glaucoma (NTG) are distinct subtypes.
    • Optic chiasm alterations may correlate with visual field defects in glaucoma.

    Purpose of the Study:

    • To investigate changes in optic chiasm width in patients with HTG and NTG.
    • To determine the relationship between chiasm size and visual field changes in these glaucoma types.

    Main Methods:

    • Retrospective analysis of MRI-measured chiasm width and visual field sensitivity (0-22 degrees).
    • Study included 9 HTG and 9 NTG patients, diagnosed via comprehensive ophthalmological and electrophysiological exams.
    • Statistical analysis involved paired t-tests and correlation coefficients.

    Main Results:

    • A statistically significant reduction in chiasm width was observed in both HTG and NTG groups compared to controls.
    • Chiasm narrowing showed a slight correlation with visual field changes in HTG (r=0.139).
    • A moderate correlation was found between chiasm narrowing and visual field changes in NTG (r=0.375).

    Conclusions:

    • Both HTG and NTG are associated with a reduced optic chiasm size.
    • The correlation between central visual field sensitivity and chiasm reduction differs between HTG and NTG.
    • These findings support the classification of HTG and NTG as distinct diagnostic entities.