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COVID-19: a potential driver of immune-mediated breast cancer recurrence?
Federica Francescangeli1, Maria Laura De Angelis1, Ann Zeuner2
1Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Abstract:
Severe coronavirus disease 2019 (COVID-19) causes a hyperactivation of immune cells, resulting in lung inflammation. Recent studies showed that COVID-19 induces the production of factors previously implicated in the reawakening of dormant breast cancer cells such as neutrophil extracellular traps (NETs). The presence of NETs and of a pro-inflammatory microenvironment may therefore promote breast cancer reactivation, increasing the risk of pulmonary metastasis. Further studies will be required to confirm the link between COVID-19 and cancer recurrence. However, an increased awareness on the potential risks for breast cancer patients with COVID-19 may lead to improved treatment strategies to prevent metastatic relapse.
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