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Association between serum pepsinogen and atherosclerotic cardiovascular disease

Xiaoling Gao1, Yanjuan Jia1, Hui Xu1

  • 1NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou, 730000, China; The Institute of Clinical Research and Translational Medicine, Gansu Provincial Hospital, Lanzhou, 730000, China.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|October 31, 2020
PubMed

Insights

Serum pepsinogens (PGs) are linked to atherosclerotic cardiovascular disease (ASCVD). Lower levels of PGI and PGR, and higher PGII, are associated with increased ASCVD risk, with PGR potentially being a reliable biomarker.

Area of Science:

  • Biochemistry
  • Cardiology
  • Gastroenterology

Background:

  • Serum pepsinogens (PGs) are established biomarkers for gastric mucosal damage.
  • Previous studies suggest a link between PGs and atherosclerosis.
  • The specific correlation between PGs and atherosclerotic cardiovascular disease (ASCVD) remains largely unexplored.

Purpose of the Study:

  • To investigate the association between serum pepsinogen levels and ASCVD.
  • To provide clinicians with insights for improved ASCVD diagnosis and treatment strategies.

Main Methods:

  • Analysis of serum PG concentrations in 8355 participants, comparing ASCVD and non-ASCVD groups.
  • Utilized non-parametric tests, Chi-squared, Fisher exact, Spearman's correlation, and binary logistic regression.
  • Employed two-piecewise linear regression to analyze nonlinear relationships.

Main Results:

  • Significant differences in serum PG concentrations were observed between ASCVD and non-ASCVD groups (P = 0.025, P < 0.001).
  • Lower levels of pepsinogen I (PGI) and pepsinogen A (PGR) correlated with higher ASCVD risk after covariate adjustment.
  • Higher levels of pepsinogen II (PGII) showed a linear association with ASCVD risk (adjusted OR = 1.16).
  • Nonlinear relationships were found for PGI/PGR with ASCVD; increased PGI (≥131 ng/mL) raised ASCVD risk (OR = 4.67), while higher PGR (≥1.65) decreased risk (OR = 0.59).

Conclusions:

  • Serum PGI and PGR exhibit nonlinear correlations with ASCVD.
  • Serum PGII demonstrates a linear correlation with ASCVD.
  • Pepsinogen A (PGR) may function as a dependable biomarker for identifying ASCVD risk.
Abstract

Keywords:
Atherosclerotic cardiovascular diseaseGastric diseasePGI/PGII ratioPepsinogen IPepsinogen II

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