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Updated: Jul 16, 2026
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Sublimation of DAN Matrix for the Detection and Visualization of Gangliosides in Rat Brain Tissue for MALDI Imaging Mass Spectrometry
Published on: March 23, 2017
Highly sensitive analysis of gangliosides in human cerebrospinal fluid with neurological diseases
T Yamanaka1, Y Hirabayashi, K Koketsu
1Department of Pediatrics, Yaizu Municipal Hospital, Japan.
The Japanese Journal of Experimental Medicine
|April 1, 1987
Abstract:
We have developed a new method for detection and determination of ganglio-series gangliosides by TLC/enzyme-immunostaining. By using this method, even 1 pmole of the gangliosides in cerebrospinal fluid (CSF) from gangliosidoses and other neurological patients could be measured quantitatively. The accumulation of the gangliosides in CSF was demonstrated from patients with gangliosidoses, thus, the diagnosis could be confirmed antemortem.
