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Related Concept Videos

Electrospray Ionization (ESI) Mass Spectrometry01:12

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Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...
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Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds
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Protein encapsulation by electrospinning and electrospraying.

Anabela Moreira1, Dan Lawson2, Lesley Onyekuru3

  • 1BIOFABICS, Rua Alfredo Allen 455, 4200-135 Porto, Portugal.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|October 31, 2020
PubMed
Summary

Electrohydrodynamic (EHD) techniques like electrospinning and electrospraying offer advanced methods for creating peptide and protein delivery systems. These methods enable precise control over drug release and preserve therapeutic molecule activity.

Keywords:
Drug deliveryElectrospinningElectrosprayingProtein encapsulationTissue engineering

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Growing interest in peptide and protein therapeutics necessitates advanced delivery systems.
  • Current delivery methods struggle to maintain biological activity and control release profiles.
  • Electrohydrodynamic (EHD) techniques offer a promising solution for these challenges.

Purpose of the Study:

  • To review the potential of various EHD methods for peptide and protein delivery.
  • To explore principles of electrospinning and electrospraying for therapeutic agent encapsulation.
  • To discuss advancements in stimuli-responsive and localized delivery systems.

Main Methods:

  • Overview of EHD principles, including electrospinning and electrospraying.
  • Exploration of blend, emulsion, and co-/multi-axial EHD techniques.
  • Literature survey on encapsulating various therapeutic proteins (enzymes, growth factors, antibodies, hormones, vaccine antigens).

Main Results:

  • EHD techniques generate high surface area-to-volume ratio structures (fibers and particles).
  • Versatile architectures and highly controllable release profiles are achievable.
  • Successful encapsulation of diverse therapeutic peptides and proteins demonstrated.

Conclusions:

  • EHD methods show significant potential for developing effective peptide and protein delivery systems.
  • Stimuli-responsive and localized delivery strategies are feasible.
  • Challenges and steps for clinical translation and scaled-up production are identified.