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Layer by layer assembly of core-corona structured solid lipid nanoparticles with β-cyclodextrin polymers.

Gulin Amasya1, Filiz Bakar-Ates2, Véronique Wintgens3

  • 1Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06560 Ankara, Turkey.

International Journal of Pharmaceutics
|October 31, 2020
PubMed
Summary

Novel core-corona solid lipid nanoparticles (SLNs) were developed using β-cyclodextrin polymers. These surface-modified SLNs demonstrate enhanced drug release and excellent biocompatibility, making them promising drug carriers.

Keywords:
Core-corona structureLayer by layer assemblyOppositely charged β-cyclodextrin polymers (poly-β-CDs)Solid lipid nanoparticles (SLN)Surface modified SLN

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Solid lipid nanoparticles (SLNs) are widely explored for drug delivery.
  • Surface modification of SLNs is crucial for improving their performance and biocompatibility.
  • Developing novel nanoarchitectures can enhance drug loading and release profiles.

Purpose of the Study:

  • To design and characterize a core-corona nanoarchitecture for surface-modified SLNs.
  • To evaluate the impact of β-cyclodextrin polymer coating on SLN properties and drug release.
  • To assess the biocompatibility of the novel SLN systems for drug delivery applications.

Main Methods:

  • Layer-by-layer assembly of oppositely charged β-cyclodextrin polymers onto a lipid core.
  • Characterization of particle size, polydispersity index, and zeta potential.
  • Morphological analysis using Transmission Electron Microscopy (TEM).
  • In vitro drug release studies and cytotoxicity assays on healthy cell lines.

Main Results:

  • Successful formation of core-corona SLNs with altered zeta potential (negative to positive) and increased surface charge density.
  • TEM confirmed the hierarchical core-corona structure.
  • Drug release was primarily diffusion-controlled, with β-cyclodextrin polymers enhancing slow/controlled release.
  • Cytotoxicity assays indicated no adverse effects on healthy cells, confirming biocompatibility.

Conclusions:

  • Layer-by-layer assembly of β-cyclodextrin polymers is an effective strategy for surface modification of SLNs.
  • The developed core-corona SLNs exhibit favorable characteristics for drug delivery, including controlled release and safety.
  • These novel nanoarchitectures hold promise for various administration routes.