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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
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Influence of chest conformation on myocardial strain parameters in healthy subjects with mitral valve prolapse

Andrea Sonaglioni1,2, Gian Luigi Nicolosi3, Michele Lombardo4

  • 1Department of Cardiology, Ospedale San Giuseppe MultiMedica, Milan, Italy. sonaglioniandrea@gmail.com.

The International Journal of Cardiovascular Imaging
|October 31, 2020
PubMed

Insights

Chest shape impacts myocardial strain in mitral valve prolapse (MVP). A tighter chest (higher modified Haller index) in MVP patients correlates with reduced cardiac strain, not intrinsic contractility issues.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biophysics

Background:

  • Chest shape variations can influence cardiac function.
  • The relationship between chest conformation and myocardial strain in mitral valve prolapse (MVP) is not well-established.
  • Understanding these factors is crucial for accurate cardiac assessment in MVP patients.

Purpose of the Study:

  • To investigate the association between chest conformation, assessed by the modified Haller index (MHI), and myocardial strain parameters in patients with MVP.
  • To determine if chest deformity contributes to altered myocardial strain in MVP.

Main Methods:

  • A case-control study involving 60 MVP patients and 60 controls.
  • Modified Haller Index (MHI) calculation to quantify chest shape.
  • Transthoracic echocardiography with 2D-speckle tracking analysis to assess left ventricular (LV) strain parameters (GLS, GCS, GRS) and LV peak twist.

Main Results:

  • MVP patients exhibited significantly higher MHI compared to controls.
  • LV ejection fraction was similar between groups.
  • MVP patients showed significantly lower GLS, GCS, GRS, and LV peak twist compared to controls.
  • Impaired myocardial strain and LV peak twist were observed in MVP patients with a tighter chest (MHI > 2.5).
  • MHI strongly inversely correlated with GLS, GCS, GRS, and LV peak twist.

Conclusions:

  • Chest deformity, specifically a tighter chest conformation (higher MHI), is associated with impaired myocardial strain parameters in MVP patients.
  • The observed reduction in myocardial strain in MVP appears to be related to chest deformity rather than intrinsic cardiac contractility dysfunction.

Keywords:
Haller indexMitral valve prolapseMyocardial strain

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