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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Endothelial dysfunction and cardiovascular risk in lupus nephritis: New roles for old players?

Daniele Mancardi1, Elisa Arrigo1, Martina Cozzi2,3

  • 1Department of Clinical and Biological Sciences, University of Torino, Torino, Italy.

European Journal of Clinical Investigation
|October 31, 2020
PubMed

Insights

Systemic lupus erythematosus (SLE) and lupus nephritis (LN) involve endothelial dysfunction, impacting cardiovascular health. Understanding these vascular changes is key to developing targeted treatments for SLE and LN patients.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) and lupus nephritis (LN) are characterized by endothelial dysfunction, contributing to cardiovascular complications.
  • Kidney damage in LN can negatively impact the cardiovascular system, increasing risks for hypertension and stroke.

Purpose of the Study:

  • To review the literature on endothelial activation and dysfunction in SLE and LN patients.
  • To explore similarities and differences in arteriovenous endothelial pathways and microcirculation versus macrocirculation.
  • To identify potential therapeutic targets for cardiovascular complications in SLE and LN.

Main Methods:

  • Comprehensive literature review of recent studies on endothelial dysfunction in SLE and LN.
  • Analysis of arteriovenous endothelial cell activation pathways.
  • Comparison of microcirculation and macrocirculation manifestations.

Main Results:

  • Endothelial dysfunction is a shared vascular component in SLE clinical manifestations and LN.
  • Kidney damage in LN exacerbates cardiovascular risk factors.
  • Specific pathways in venous versus arterial endothelial cells and microcirculation versus macrocirculation require further elucidation.

Conclusions:

  • Critical summary of current data on endothelial dysfunction in SLE/LN is vital for developing new treatments.
  • Further research into arteriovenous differences and micro/macrocirculation is needed.
  • Targeting endothelial dysfunction may offer novel therapeutic strategies for cardiovascular complications in SLE and LN.

Keywords:
endothelial dysfunctionlupus erythematousnephritis

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