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Updated: Aug 10, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
The evolution of chemotherapy of lymphomas of adults
1National Cancer Institute, Bethesda, Maryland 20205.
Abstract:
Patients with advanced stages of Hodgkin's disease and diffuse large-cell lymphoma are curable with combination chemotherapy. The studies conducted at the National Cancer Institute over the past 20 years are reviewed along with pertinent studies conducted elsewhere. It is the author's contention that there is room for considerable improvement in results with existing therapy if greater attention is paid to dosing and less to trying to improve, by slight modifications, on treatments that should be regarded as a temporary stage in the development of standard lymphoma treatment.
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