Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.5K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.5K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

7.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of next generation sequencing studies on the diagnosis of BAP1 inactivated melanocytic tumors.

Human pathology·2026
Same author

eIF4E: A New Diagnostic Biomarker for Mycosis Fungoides.

Experimental dermatology·2026
Same author

The Impact of Next-Generation Sequencing on Interobserver Agreement and Diagnostic Accuracy of Deep Penetrating Melanocytic Neoplasms.

Journal of cutaneous pathology·2025
Same author

Cutaneous AL-Type Amyloidomas as a Variant of Primary Cutaneous Marginal Zone Lymphoma: A Series of 30 Patients.

The American Journal of dermatopathology·2025
Same author

European Organisation for Research and Treatment of Cancer, United States Cutaneous Lymphoma Consortium and International Society for Cutaneous Lymphomas consensus recommendations for management and treatment of cutaneous lymphoproliferative disorders.

The British journal of dermatology·2025
Same author

Chronotherapy With Once-Daily Osilodrostat Improves Cortisol Rhythm, Quality of Life, and Sleep in Cushing's Syndrome.

The Journal of clinical endocrinology and metabolism·2025

Related Experiment Video

Updated: Dec 3, 2025

Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

10.2K

Merkel cell carcinoma: A review.

Noreen M Walsh1,2, Lorenzo Cerroni3

  • 1Department of Pathology, Queen Elizabeth II Health Sciences Center, Nova Scotia Health Authority (Central Zone), Halifax, Nova Scotia, Canada.

Journal of Cutaneous Pathology
|October 31, 2020
PubMed
Summary

Merkel cell carcinoma, a rare skin cancer, is increasingly studied. New research reveals viral and UV causes, impacting prognosis and leading to effective immune checkpoint inhibitor therapies.

Keywords:
Merkel cell carcinomaMerkel cell polyomavirusimmune checkpoint inhibitorsneuroendocrine carcinoma

More Related Videos

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
12:16

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Published on: March 13, 2013

21.6K
Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

2.7K

Related Experiment Videos

Last Updated: Dec 3, 2025

Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

10.2K
Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
12:16

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Published on: March 13, 2013

21.6K
Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

2.7K

Area of Science:

  • Dermatology
  • Oncology
  • Virology

Background:

  • Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer.
  • MCC incidence is rising, particularly in elderly individuals, often on the head and neck.
  • Recent research links MCC to Merkel cell polyomavirus (MCPyV) and ultraviolet (UV) radiation.

Purpose of the Study:

  • To provide an overview of current knowledge on Merkel cell carcinoma.
  • To highlight recent advancements in understanding MCC pathogenesis and treatment.
  • To emphasize the dermatopathologic features of MCC.

Main Methods:

  • Review of recent scientific literature on Merkel cell carcinoma.
  • Analysis of etiological factors, including viral and environmental influences.
  • Evaluation of therapeutic responses, particularly to immune checkpoint inhibitors.

Main Results:

  • Two distinct pathogenic subsets of MCC identified: MCPyV-positive and UV-induced.
  • MCPyV-associated MCC generally has a better prognosis than UV-induced MCC.
  • MCC demonstrates significant responsiveness to immune checkpoint inhibition therapy.

Conclusions:

  • Understanding the distinct etiologies of MCC is crucial for prognosis.
  • Immune checkpoint inhibitors represent a major therapeutic advancement for Merkel cell carcinoma.
  • Continued research into MCC pathogenesis and dermatopathology is essential for improving patient outcomes.