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Serum Uric Acid may be Associated with Left Ventricular Diastolic Dysfunction in Military Individuals

Chung-Ming Tu1,2, Guo-Shiang Tseng3, Cheng-Wei Liu4,5

  • 1Cardiology Division of Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City 22060, Taiwan.

Military Medicine
|October 31, 2020
PubMed

Insights

High serum uric acid (SUA) is linked to left ventricular diastolic dysfunction (LVDD) in military personnel. Keeping SUA levels normal may help prevent LVDD development.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Clinical Research

Background:

  • Serum uric acid (SUA) is a metabolic byproduct.
  • Left ventricular diastolic dysfunction (LVDD) is a common cardiac condition.
  • The relationship between SUA and LVDD in military populations is not well-established.

Purpose of the Study:

  • To investigate the correlation between serum uric acid levels and left ventricular diastolic dysfunction criteria.
  • To determine the association between elevated SUA and LVDD in military individuals.

Main Methods:

  • Prospective enrollment of 268 military individuals evaluated for electrocardiographic abnormalities.
  • Definition of hyperuricemia as SUA ≥7 mg/dL (men) or ≥6 mg/dL (women).
  • Assessment of LVDD criteria and left ventricular hypertrophy using echocardiographic guidelines.

Main Results:

  • Serum uric acid showed weak correlations with left atrial diameter and left ventricular mass index (LVMI).
  • The hyperuricemic group exhibited higher LVMI and increased prevalence of LVDD criteria (septal e' velocity <7 cm/s, lateral e' velocity <10 cm/s, average E/e' >14).
  • Elevated SUA was significantly associated with septal e' velocity <7 cm/s in multivariate analysis (adjusted HR: 2.398).

Conclusions:

  • Elevated serum uric acid is significantly associated with specific criteria for left ventricular diastolic dysfunction in military personnel.
  • Maintaining normal SUA levels may be a strategy to prevent the development of LVDD.
Abstract

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