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Related Concept Videos

Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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UK Stem Cell Bank.

Orla O'Shea1, Elsa Abranches1

  • 1UK Stem Cell Bank, Advanced Therapies Division, National Institute for Biological Standards and Control (NIBSC), Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK.

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Summary
This summary is machine-generated.

The UK Stem Cell Bank (UKSCB), established in 2003, provides quality-controlled stem cell lines for research and therapy development. It supports the cell-based therapy field with advanced facilities and diverse stem cell resources.

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Area of Science:

  • Biomedical Sciences
  • Regenerative Medicine
  • Cell Biology

Background:

  • The UK Stem Cell Bank (UKSCB) was founded in 2003 to advance stem cell research and therapies.
  • High-quality, controlled stem cell lines are crucial for reproducible scientific findings and clinical applications.

Purpose of the Study:

  • To highlight the role and capabilities of the UK Stem Cell Bank (UKSCB) in supporting the stem cell research community.
  • To showcase the available resources, including research-grade and EUTCD-grade stem cell lines and reference reagents.

Main Methods:

  • The UKSCB operates state-of-the-art facilities.
  • It employs highly trained staff for quality control and management of stem cell lines.
  • The bank maintains a diverse portfolio of stem cell products.

Main Results:

  • The UKSCB has successfully facilitated the use and sharing of stem cell lines since its establishment.
  • A range of research and EUTCD-grade stem cell lines are available.
  • Reference reagents are under development to further support the field.

Conclusions:

  • The UKSCB is a key resource for the advancement of stem cell research and the clinical development of cell-based therapies.
  • Its comprehensive services and quality-controlled products position it as a vital contributor to the regenerative medicine landscape.