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Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients

Hamed Valizadeh1, Samaneh Abdolmohammadi-Vahid2, Svetlana Danshina3

  • 1Tuberculosis and Lung Disease Research Center of Tabriz University of Medical Sciences, Tabriz, Iran; Department of Internal Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

International Immunopharmacology
|October 31, 2020
PubMed

Insights

Nano-curcumin may reduce key inflammatory cytokines, IL-1β and IL-6, in COVID-19 patients. This anti-inflammatory agent shows potential for improving clinical outcomes and recovery from the disease.

Area of Science:

  • Immunology
  • Pharmacology
  • Infectious Diseases

Background:

  • COVID-19 causes severe complications due to excessive inflammatory cytokine production.
  • No definitive treatment exists, highlighting the need for novel therapeutic strategies.
  • Nano-curcumin is explored for its potential anti-inflammatory properties.

Purpose of the Study:

  • To investigate the effect of Nano-curcumin on modulating inflammatory cytokines in COVID-19 patients.
  • To assess changes in Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α), and Interleukin-18 (IL-18) levels.

Main Methods:

  • A study involving 40 COVID-19 patients and 40 healthy controls.
  • COVID-19 patients were divided into Nano-curcumin and placebo groups.
  • Real-time PCR and ELISA were used to measure mRNA expression and cytokine secretion.

Main Results:

  • COVID-19 patients exhibited significantly higher levels of IL-1β, IL-6, TNF-α, and IL-18 compared to controls.
  • Nano-curcumin treatment significantly decreased IL-6 and IL-1β expression and secretion.
  • IL-18 mRNA and TNF-α levels were not significantly affected by Nano-curcumin.

Conclusions:

  • Nano-curcumin demonstrates potential as an anti-inflammatory agent for COVID-19.
  • It may modulate elevated IL-1β and IL-6, potentially improving patient recovery.
  • Further research is warranted to confirm clinical efficacy.
Abstract

Keywords:
COVID-19Cytokine stormIL-1βIL-6Nano-curcumin

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