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Updated: Dec 3, 2025
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Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
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Changes in plasma bile acids are associated with gallbladder stones and polyps
Linshi Wu1,2, Yinping Wang1,2, Sibo Zhu3,4
1Department of General Surgery, South Campus, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
BMC Gastroenterology
|November 1, 2020
Summary
Gallbladder disease (GBD) is linked to altered bile acid (BA) metabolism, with secondary BAs increasing and primary BAs decreasing in patients. Ursodeoxycholic acid (UDCA) showed potential anti-inflammatory effects.
Area of Science:
- Gastroenterology
- Metabolomics
- Bile Acid Research
Background:
- Gallbladder disease (GBD) development is associated with bile acid (BA) metabolism.
- Increased BA circulation elevates biliary cancer risk.
- Changes in plasma BA profiles in benign GBDs like gallbladder stones and polyps remain unclear.
Purpose of the Study:
- Compare plasma BA profiles in patients with cholecystolithiasis and non-neoplastic polyps versus healthy controls.
- Characterize alterations in circulating BA metabolites.
- Explore correlations between BA profiles, demographics, and laboratory indices.
Main Methods:
- Analyzed plasma BA profiles of 330 subjects (13 controls, 292 cholecystolithiasis, 25 non-neoplastic polyps).
- Quantitated 14 BA metabolites using liquid chromatography and mass spectrometry.
- Performed statistical and regression analyses on demographics and lab data.
Main Results:
- Females had a higher prevalence of GBD.
- Cholelithiasis and polyps showed increased total secondary BAs and decreased primary BAs.
- Plasma levels of UDCA, TUDCA, GUDCA, TCDCA, and GCDCA were significantly reduced in GBD patients.
Conclusions:
- Secondary BA levels are elevated in patients with cholecystolithiasis and non-neoplastic polyps.
- Reduced UDCA levels correlate with increased white blood cell count and neutrophil percentage.
- UDCA may exert an anti-inflammatory effect in GBD.
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