Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

701
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
701
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

227
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
227
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

3.1K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
3.1K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.5K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

211
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
211
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

283
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
283

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypoxia-driven microRNA-27b underlies pathologic cardiac endoreplication in heart disease.

Signal transduction and targeted therapy·2026
Same author

Interleukin 11-Induced MicroRNAs as Functional Mediators and Circulating Biomarkers of Cardiac Fibrosis.

Circulation research·2026
Same author

Circular PVT1 promotes cardiac fibroblast activation interacting with miR-30a-5p and miR-125b-5p.

Cell death & disease·2025
Same author

Circulating Non-Coding RNAs as Indicators of Fibrosis and Heart Failure Severity.

Cells·2025
Same author

Blockade of YAP Mechanoactivation Prevents Neointima Formation and Adverse Remodeling in Arterialized Vein Grafts.

Journal of the American Heart Association·2025
Same author

miR-210 overexpression increases pressure overload-induced cardiac fibrosis.

Non-coding RNA research·2025

Related Experiment Video

Updated: Dec 3, 2025

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart
08:22

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart

Published on: April 15, 2020

19.0K

Noncoding RNAs implication in cardiovascular diseases in the COVID-19 era.

S Greco1, A Madè1, C Gaetano2

  • 1Molecular Cardiology Laboratory, IRCCS Policlinico San Donato, San Donato Milanese, 20097, Milan, Italy.

Journal of Translational Medicine
|November 1, 2020
PubMed
Summary

Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection causes COVID-19, impacting the cardiovascular system. Noncoding RNAs may play a role in COVID-19

Keywords:
COVID-19,Cardiovascular diseaseNoncoding RNAs,SARS-CoV-2,Transcriptomics

More Related Videos

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.8K
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.8K

Related Experiment Videos

Last Updated: Dec 3, 2025

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart
08:22

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart

Published on: April 15, 2020

19.0K
In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.8K
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.8K

Area of Science:

  • Cardiovascular Medicine
  • Virology
  • Molecular Biology

Background:

  • COVID-19, caused by SARS-CoV-2, primarily affects the respiratory system but also causes significant cardiovascular damage.
  • Cardiovascular homeostasis relies on precise gene expression regulation by various RNA molecules, including messenger RNAs (mRNAs) and noncoding RNAs.
  • Dysregulation of noncoding RNAs is increasingly recognized as a key factor in cardiovascular disease pathophysiology.

Purpose of the Study:

  • To explore the potential involvement of noncoding RNAs in the mechanisms underlying COVID-19.
  • To investigate the utility of noncoding RNAs as potential biomarkers for clinical applications in COVID-19 patients.

Main Methods:

  • This review synthesizes current research on the molecular mechanisms of COVID-19 and cardiovascular complications.
  • It examines the established roles of noncoding RNAs in cardiovascular diseases.
  • The discussion focuses on the intersection of noncoding RNA biology and SARS-CoV-2 infection.

Main Results:

  • SARS-CoV-2 infection can lead to both direct and indirect cardiovascular injury.
  • Noncoding RNAs are implicated in the complex pathophysiology of cardiovascular damage associated with COVID-19.
  • Alterations in noncoding RNA expression patterns are observed in cardiovascular diseases.

Conclusions:

  • Noncoding RNAs represent a promising area for understanding COVID-19's cardiovascular impact.
  • Further research into noncoding RNAs could lead to novel diagnostic biomarkers and therapeutic targets for COVID-19-related cardiovascular complications.