Noncoding RNAs implication in cardiovascular diseases in the COVID-19 era

Area of Science:

• Cardiovascular Medicine
• Virology
• Molecular Biology

Background:

• COVID-19, caused by SARS-CoV-2, primarily affects the respiratory system but also causes significant cardiovascular damage.
• Cardiovascular homeostasis relies on precise gene expression regulation by various RNA molecules, including messenger RNAs (mRNAs) and noncoding RNAs.
• Dysregulation of noncoding RNAs is increasingly recognized as a key factor in cardiovascular disease pathophysiology.

Purpose of the Study:

• To explore the potential involvement of noncoding RNAs in the mechanisms underlying COVID-19.
• To investigate the utility of noncoding RNAs as potential biomarkers for clinical applications in COVID-19 patients.

Main Methods:

• This review synthesizes current research on the molecular mechanisms of COVID-19 and cardiovascular complications.
• It examines the established roles of noncoding RNAs in cardiovascular diseases.
• The discussion focuses on the intersection of noncoding RNA biology and SARS-CoV-2 infection.

Main Results:

• SARS-CoV-2 infection can lead to both direct and indirect cardiovascular injury.
• Noncoding RNAs are implicated in the complex pathophysiology of cardiovascular damage associated with COVID-19.
• Alterations in noncoding RNA expression patterns are observed in cardiovascular diseases.

Conclusions:

• Noncoding RNAs represent a promising area for understanding COVID-19's cardiovascular impact.
• Further research into noncoding RNAs could lead to novel diagnostic biomarkers and therapeutic targets for COVID-19-related cardiovascular complications.