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Updated: Dec 3, 2025

Osteoclast Derivation from Mouse Bone Marrow
Published on: November 6, 2014
Development of prohibitin ligands against osteoporosis
Redouane Tabti1, François Lamoureux2, Céline Charrier2
1Laboratory of Regenerative Nanomedicine (RNM), INSERM U 1260, CRBS, Rue Eugène Boeckel, 67000, Strasbourg, France; LCIMN Laboratory, Faculty of Technology, University Ferhat Abbas, Sétif, Algeria.
Abstract:
Current therapeutic approaches to osteoporosis display some potential adverse effects and a limited efficacy on non-vertebral fracture reduction. Some sulfonylamidines targeting the scaffold proteins prohibitins-1 and 2 (PHB1/2) have been showed to inhibit the formation of osteoclasts in charge of bone resorption. Herein, we report the development of a second generation of anti-osteoclastic PHB ligands. The most potent compound, IN45, showed 88% inhibition at the low concentration of 5 μM, indicates that it might serve as a basis for the development of new antiosteoporotic drugs.
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