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Updated: Dec 3, 2025

Routine Screening Method for Microparticles in Platelet Transfusions
Published on: January 31, 2018
Non-Alloimmune Mechanisms of Thrombocytopenia and Refractoriness to Platelet Transfusion
Roger Belizaire1, Robert S Makar2
1Associate Director, Adult Transfusion Medicine, Brigham and Women's Hospital, Boston, MA.
Abstract:
Refractoriness to platelet transfusion is a common clinical problem encountered by the transfusion medicine specialist. It is well recognized that most causes of refractoriness to platelet transfusion are not a consequence of alloimmunization to human leukocyte, platelet-specific, or ABO antigens, but are a consequence of platelet sequestration and consumption. This review summarizes the clinical factors that result in platelet refractoriness and highlights recent data describing novel biological mechanisms that contribute to this clinical problem.
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