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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Conversion of Human Induced Pluripotent Stem Cells iPSCs into Functional Spinal and Cranial Motor Neurons Using PiggyBac Vectors
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Modelling multiple sclerosis using induced pluripotent stem cells.

Júlia Martínez-Larrosa1, Clara Matute-Blanch1, Xavier Montalban1

  • 1Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

Journal of Neuroimmunology
|November 1, 2020
PubMed
Summary
This summary is machine-generated.

Induced pluripotent stem cells (iPSCs) offer promise for multiple sclerosis (MS) research and potential therapies by creating patient-specific neural cells. However, challenges remain in their application for MS treatment and disease modeling.

Keywords:
Induced pluripotent stem cellsMultiple sclerosisNeurodegenerationNeuroprotection

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Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Immunology

Background:

  • Multiple Sclerosis (MS) is a leading cause of neurological disability in young adults.
  • Current MS therapies cannot prevent neurodegeneration or halt disease progression.
  • Effective disease models are lacking for MS research.

Purpose of the Study:

  • To review the challenges and potential of induced pluripotent stem cells (iPSCs) in multiple sclerosis (MS).
  • To focus on functional studies, limitations, and future perspectives of iPSC-derived cells in MS.
  • To explore iPSC applications in MS disease modeling, drug screening, and cell therapy.

Main Methods:

  • Review of existing literature on iPSC applications in MS.
  • Analysis of functional studies using iPSC-derived cells for MS.
  • Identification of limitations and future research directions.

Main Results:

  • iPSCs enable the generation of patient-specific neural cells for MS research.
  • Significant challenges exist in translating iPSC technology to effective MS therapies.
  • Functional studies highlight both potential and limitations of iPSC-derived cells.

Conclusions:

  • iPSC technology holds promise for advancing MS understanding and developing new treatments.
  • Overcoming current challenges is crucial for realizing the therapeutic potential of iPSCs in MS.
  • Further research is needed to optimize iPSC-based strategies for neuroprotection and disease modification in MS.