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Related Experiment Videos

Evoked potentials predict the clinical changes in a multiple sclerosis drug study.

M R Nuwer1, J W Packwood, L W Myers

  • 1Department of Neurology, School of Medicine, University of California, Los Angeles.

Neurology
|November 1, 1987
PubMed
Summary
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Evoked potential (EP) tests are sensitive, objective measurements for multiple sclerosis (MS) therapeutic trials. These tests detected treatment-related changes a year earlier than standard neurological exams.

Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Immunology

Background:

  • Chronic progressive multiple sclerosis (MS) requires sensitive outcome measures for clinical trials.
  • Azathioprine and steroids are used in MS treatment, necessitating objective assessment of efficacy.
  • Evoked potentials (EPs) offer a potential objective measure of neurological function.

Purpose of the Study:

  • To evaluate the utility of visual, brainstem auditory, and somatosensory evoked potentials (EPs) as objective outcome measures in a chronic progressive MS clinical trial.
  • To compare the sensitivity of EPs to changes induced by azathioprine with or without steroids against the Standard Neurological Examination (SNE).

Main Methods:

  • A 3-year, double-blind, placebo-controlled study involving patients with chronic progressive MS.

Related Experiment Videos

  • Annual testing using visual, brainstem auditory, and median nerve somatosensory evoked potential (EP) tests.
  • Comparison of EP changes (latency values) with Standard Neurological Examination (SNE) scores.

    • Main Results:

    • Treatment-related changes in visual and somatosensory EPs were detected statistically one year prior to SNE score differences.
    • EP changes demonstrated substantially greater statistical significance compared to other clinical scales.
    • Utilizing EP latency values, rather than simple change criteria, increased the degree of statistical significance.

    Conclusions:

    • Evoked potentials (EPs) are sensitive and objective measurements valuable in multiple sclerosis (MS) therapeutic trials.
    • EPs can detect treatment effects earlier than the Standard Neurological Examination.
    • EP latency measurements enhance the statistical power for detecting treatment effects in MS studies.