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Updated: Dec 2, 2025

Ex Situ Normothermic Machine Perfusion of Donor Livers
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Cell therapy during machine perfusion.

Emily R Thompson1, Chloe Connelly1, Simi Ali1

  • 1Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

Transplant International : Official Journal of the European Society for Organ Transplantation
|November 1, 2020
PubMed
Summary
This summary is machine-generated.

Normothermic machine perfusion preserves marginal organs for transplant. This technology offers opportunities for organ reconditioning and repair using cellular therapies before transplantation.

Keywords:
cell therapymachine perfusionpreservationregenerative medicinetransplant

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Area of Science:

  • Transplantation science
  • Organ preservation technologies
  • Regenerative medicine

Background:

  • Increasing demand for organ transplants necessitates using organs from extended criteria or donation after circulatory death donors.
  • Marginal organ function is a challenge in transplantation.
  • Advances in organ preservation are crucial for improving transplant outcomes.

Purpose of the Study:

  • To discuss the potential of normothermic machine perfusion (NMP) technology.
  • To highlight NMP's role in organ reconditioning and repair.
  • To explore future research directions in machine perfusion for transplantation.

Main Methods:

  • Review of current literature on organ preservation and machine perfusion.
  • Discussion of normothermic machine perfusion principles and applications.
  • Exploration of cellular therapies in conjunction with machine perfusion.

Main Results:

  • Normothermic machine perfusion allows organs to maintain physiological function ex-vivo.
  • NMP provides a platform for organ reconditioning, repair, and regeneration.
  • Integration of cellular therapies with NMP shows promise for improving marginal organ viability.

Conclusions:

  • Machine perfusion technology, particularly NMP, is a significant advancement in organ preservation.
  • NMP opens new avenues for utilizing marginal organs through pre-transplant reconditioning.
  • Further research is needed to fully realize the potential of NMP and cellular therapies in transplantation.