Related Experiment Video
Updated: Dec 2, 2025
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
The Future of Childhood Cancer Survivorship: Challenges and Opportunities for Continued Progress
Stephanie B Dixon1, Eric J Chow2, Lars Hjorth3
1Department of Oncology, St. Jude Children's Research Hospital, MS 735, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Abstract:
As treatment evolves and the population who survive childhood cancer ages and increases in number, researchers must use novel approaches to prevent, identify and mitigate adverse effects of treatment. Future priorities include collaborative efforts to pool large cohort data to improve detection of late effects, identify late effects of novel therapies, and determine the contribution of genetic factors along with physiologic and accelerated aging among survivors. This knowledge should translate to individual risk prediction and prevention strategies. Finally, we must utilize health services research and implementation science to improve adoption of survivorship care recommendations outside of specialized pediatric oncology centers.
Insights
As cancer treatments advance, survivors need new strategies to manage long-term side effects. Future research will focus on large data analysis, novel therapies, aging, and genetics to improve survivor care and prevention.
Area of Science:
- Pediatric Oncology
- Cancer Survivorship Research
- Health Services Research
Background:
- Increasing number of childhood cancer survivors require long-term care.
- Evolving cancer treatments necessitate novel approaches to manage adverse effects.
- Focus on preventing, identifying, and mitigating treatment-related toxicities is crucial.
Purpose of the Study:
- Outline future research priorities in pediatric cancer survivorship.
- Emphasize the need for novel approaches to manage late effects of cancer treatment.
- Highlight the importance of improving survivorship care delivery.
Main Methods:
- Collaborative efforts to pool large cohort data.
- Analysis of late effects from novel cancer therapies.
- Investigation of genetic factors, physiological aging, and accelerated aging in survivors.
Main Results:
- Need for improved detection of late effects.
- Identification of late effects associated with novel therapies.
- Understanding the contribution of genetic and aging factors to long-term health.
Conclusions:
- Future research should focus on data pooling and novel therapy effects.
- Individualized risk prediction and prevention strategies are essential.
- Implementation science is key to adopting survivorship care recommendations universally.
Related Concept Videos
01:21Cancer Survival Analysis
02:56Treatment Resistant Cancers
02:07Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:30Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:40Cancer Stem Cells and Tumor Maintenance
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...