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Updated: Dec 2, 2025

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
[Therapeutic and endovascular management of cerebral mycotic aneurysms]
Abstract:
Infective endocardites are associated with both ischemic and hemorrhagic neurological complications and also with cerebral abscesses and the development of "mycotic" aneurysms, which are detected in about 5 % of patients in the acute and sub-acute phase of the infection. Data about their natural history and their hemorrhagic risk are scarce and fragmented. The therapeutic management is represented by the medical treatment of the infection with interventional abstention, the surgical treatment and the endovascular approach by selective embolization of the aneurysm. No evidence is provided concerning the superiority of a specific approach. Mycotic aneurysms remain a diagnostic and therapeutic challenge and their management is necessarily based on a multidiscplinary approach.
Insights
Infective endocarditis can cause neurological issues like mycotic aneurysms. Current data on their natural history and bleeding risk is limited, with no single best treatment approach identified.
Area of Science:
- Neurology
- Infectious Diseases
- Cardiology
Background:
- Infective endocarditis frequently leads to neurological complications.
- Mycotic aneurysms occur in approximately 5% of patients during the acute/sub-acute infection phase.
- Existing data on mycotic aneurysm natural history and hemorrhagic risk is fragmented.
Purpose of the Study:
- To review the diagnostic and therapeutic challenges of mycotic aneurysms.
- To discuss the limited evidence regarding optimal management strategies.
- To highlight the need for a multidisciplinary approach.
Main Methods:
- Literature review of mycotic aneurysms associated with infective endocarditis.
- Analysis of diagnostic methods and treatment options (medical, surgical, endovascular).
- Assessment of available data on natural history and hemorrhagic risk.
Main Results:
- Mycotic aneurysms are a recognized complication of infective endocarditis.
- Treatment options include medical management, surgical intervention, and selective embolization.
- No definitive evidence supports the superiority of any single therapeutic approach.
Conclusions:
- Mycotic aneurysms present significant diagnostic and therapeutic challenges.
- Management requires a comprehensive, multidisciplinary strategy.
- Further research is needed to clarify natural history and optimize treatment outcomes.
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