On occasion of the 200th anniversary of the birthday of Hermann von Helmholtz the article presents a historical review on the development of audiology over the past two centuries. Modern audiology is considered to be a multidisciplinary field addressing clinical work and research on all aspects of hearing impairment, particularly prevention/protection, diagnostics and treatment of hearing problems as well as rehabilitation of patients with any degree of hearing loss. To cover all these subjects comprehensively would go beyond the scope of a journal article. Therefore, the review focuses on two of these domains, namely hearing research and diagnostic procedures as representatives for the other areas of audiology being equally important. The paper concludes with a brief look into the development of the organizational structures of audiology and a summary.