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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Drug Product Performance: In Vitro–In Vivo Correlation01:20

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In pharmaceutical development, it's crucial to establish a predictive in vitro–in vivo correlation (IVIVC) for two or more formulations to gain a comprehensive understanding of release properties. IVIVC reduces the need for costly in vivo studies and facilitates the establishment of meaningful dissolution specifications with significant cost savings and decreased regulatory burden. Furthermore, a meaningful IVIVC should predict Cmax and AUC within 20%, aligning with FDA guidance while...
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Infertility in Males01:23

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Updated: Dec 2, 2025

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery
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In-vitro maturation versus IVF: a cost-effectiveness analysis.

Sanne C Braam1, Vu N A Ho2, Toan D Pham2

  • 1Department of Obstetrics and Gynaecology Amsterdam University Medical Center, University of Amsterdam, Netherlands.

Reproductive Biomedicine Online
|November 2, 2020
PubMed
Summary

In vitro maturation (IVM) is a more cost-effective option than in vitro fertilization (IVF) for women with a high antral follicle count (AFC), despite a slightly lower live birth rate. This analysis highlights IVM

Keywords:
Cost-effectivenessIVFIVMIn-vitro maturation

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Area of Science:

  • Reproductive Endocrinology
  • Health Economics
  • Assisted Reproductive Technology

Background:

  • In vitro maturation (IVM) and in vitro fertilization (IVF) are key assisted reproductive technologies.
  • Women with a high antral follicle count (AFC) represent a specific demographic for fertility treatments.
  • Understanding the cost-effectiveness of different ARTs is crucial for patient and healthcare provider decision-making.

Purpose of the Study:

  • To compare the costs and effectiveness of in vitro maturation (IVM) versus in vitro fertilization (IVF).
  • To evaluate these treatments specifically in women diagnosed with a high antral follicle count (AFC).

Main Methods:

  • A cost-effectiveness analysis (CEA) was conducted using data from a retrospective cohort study.
  • Effectiveness was measured by cumulative live birth rate (LBR) within 12 months post-treatment.
  • Resource utilization and costs were collected, and non-parametric bootstrap resampling was used for analysis.

Main Results:

  • The cumulative live birth rate (LBR) was 39.3% for IVM versus 49.8% for IVF.
  • Ovarian hyperstimulation syndrome (OHSS) occurred in 3.5% of IVF cases but not in the IVM group.
  • Mean costs were €4300 for IVM and €6493 for IVF, with an incremental cost-effectiveness ratio (ICER) of €20,144 per additional live birth with IVF.

Conclusions:

  • In vitro maturation (IVM) presents a less expensive treatment pathway compared to in vitro fertilization (IVF) for women with a high AFC.
  • While IVM demonstrates lower cumulative live birth rates, its economic advantage is significant.
  • The findings support IVM as a viable, cost-effective alternative in assisted reproductive technology for this patient group.