Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

7.4K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
7.4K
Dissociative Disorders01:27

Dissociative Disorders

292
Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
292
Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

524
Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
524
Depolarizing Blockers: Mechanism of Action01:28

Depolarizing Blockers: Mechanism of Action

2.4K
Depolarizing blockers act on skeletal muscle fibers' membranes and induce their depolarization. Most depolarizing blockers have two quaternary N+ atoms that bind the nicotinic acetylcholine receptors and cause neuromuscular blockade within minutes.
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Frontal alpha asymmetry and NoGo N2 amplitude interact to explain non-supportive parenting practices.

Scientific reports·2026
Same author

Lights On or Off? The Efficacy of Light Therapy as Add-On to Cognitive Behavioural Therapy for Insomnia-A Pilot Study.

Journal of sleep research·2026
Same author

Ru-SATED scale and Sleep Health Index: A systematic review of two leading multidimensional sleep health measures and frameworks across the globe.

Sleep medicine reviews·2026
Same author

Obsessive-compulsive symptoms and inflammatory brain changes detected using an innovative multimodal diagnostic work-up.

Journal of neuroimmunology·2026
Same author

Neural processing of emotional stimuli before and after cognitive behavioural therapy for insomnia.

Sleep medicine·2026
Same author

Multi-voxel MR-spectroscopy signatures and associations with EEG network hyperexcitability and clinical symptomatology in borderline personality disorder.

Frontiers in psychiatry·2026
Same journal

Diversity of words and words for diversity.

Frontiers in psychiatry·2026
Same journal

Integration of transcriptome profiling to identify key genes involved in the interplay between oxidative stress and mitophagy in major depressive disorder, followed by multidimensional phenotypic validation.

Frontiers in psychiatry·2026
Same journal

Diagnosis of prolonged grief disorder among older adults: mapping physicians' knowledge and practice, and evaluating the effectiveness of a brief targeted training program.

Frontiers in psychiatry·2026
Same journal

A gender-emotion interaction multi-task network for depression recognition via transformer-based multimodal fusion.

Frontiers in psychiatry·2026
Same journal

Data-driven mechanistic analysis of digital therapeutic-assisted training and evaluation of personalized protocol effects in children with attention deficit/hyperactivity disorder.

Frontiers in psychiatry·2026
Same journal

Persistent neuropsychiatric dysfunction following chronic tiletamine-containing e-cigarette use: a case report.

Frontiers in psychiatry·2026
See all related articles

Related Experiment Video

Updated: Dec 2, 2025

Acute Dissociation of Lamprey Reticulospinal Axons to Enable Recording from the Release Face Membrane of Individual Functional Presynaptic Terminals
12:01

Acute Dissociation of Lamprey Reticulospinal Axons to Enable Recording from the Release Face Membrane of Individual Functional Presynaptic Terminals

Published on: October 1, 2014

9.1K

Dissociating Slow Responses From Slow Responding.

Gayatri Salunkhe1, Bernd Feige2, Christopher W N Saville3

  • 1Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Frontiers in Psychiatry
|November 2, 2020
PubMed
Summary
This summary is machine-generated.

Increased Intra-Subject Variability (ISV) in ADHD is better understood using ex-Gaussian measures. These measures separate response slowness from overall speed, revealing ADHD patients make more slow responses but are not generally slower than controls.

Keywords:
attention-deficit/hyperactivity disorder (ADHD)ex-Gaussian modelingintra-subject variabilityprincipal components analysesresponse speed

More Related Videos

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals
08:38

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals

Published on: May 25, 2011

15.9K
Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm
12:12

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Published on: May 14, 2014

10.9K

Related Experiment Videos

Last Updated: Dec 2, 2025

Acute Dissociation of Lamprey Reticulospinal Axons to Enable Recording from the Release Face Membrane of Individual Functional Presynaptic Terminals
12:01

Acute Dissociation of Lamprey Reticulospinal Axons to Enable Recording from the Release Face Membrane of Individual Functional Presynaptic Terminals

Published on: October 1, 2014

9.1K
Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals
08:38

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals

Published on: May 25, 2011

15.9K
Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm
12:12

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Published on: May 14, 2014

10.9K

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Increased Intra-Subject Variability (ISV) is a potential endophenotype for Attention-Deficit/Hyperactivity Disorder (ADHD).
  • Understanding the relationship between ISV and response speed is crucial for ADHD research, as individuals with ADHD exhibit high variability but are not typically slower overall.

Purpose of the Study:

  • To investigate the relationship between response variability and speed in ADHD.
  • To differentiate between response slowness and overall response speed using advanced statistical measures.

Main Methods:

  • Dimensional analyses were applied to differentiated performance measures.
  • Ex-Gaussian measures, specifically tau (τ) and mu (μ), were utilized.
  • Data from ADHD studies and young healthy adults (N=70) were analyzed.

Main Results:

  • Reaction time standard deviation and mean reaction time were highly correlated in both ADHD patients and healthy adults, failing to dissociate.
  • Ex-Gaussian tau (τ) showed minimal variance with Gaussian mu (μ), successfully dissociating slow responses from response speed.
  • ADHD patients exhibited more slow responses, but their overall speed was comparable to controls.

Conclusions:

  • Ex-Gaussian measures are valuable for disentangling ISV from response speed in ADHD research.
  • These measures can accurately characterize performance differences in ADHD, highlighting increased slow responses rather than general slowness.