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Maternal Immunological Adaptation During Normal Pregnancy

Bahaa Abu-Raya1,2,3,4, Christina Michalski2,3,4, Manish Sadarangani1,2,3,4

  • 1Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC, Canada.

Frontiers in Immunology
|November 2, 2020
PubMed

The risk and severity of specific infections are increased during pregnancy due to a combination of physiological and immunological changes. Characterizing the maternal immune system during pregnancy is important to understand how the maternal immune system maintains tolerance towards the allogeneic fetus. This may also inform strategies to prevent maternal fatalities due to infections and optimize maternal vaccination to best protect the mother-fetus dyad and the infant after birth. In this review, we describe what is known about the immunological changes that occur during a normal pregnancy.

Keywords:
cellular immune responsefetalgestationhumoral immune responseimmune systemimmunity

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