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Updated: Dec 2, 2025

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
The Promise of Big Data and Digital Solutions in Building a Cardiovascular Learning System: Opportunities and
Makoto Mori1,2, Rohan Khera3, Zhenqiu Lin1,2
1YALE SCHOOL OF MEDICINE, NEW HAVEN, CONNECTICUT.
Abstract:
The learning health system is a conceptual model for continuous learning and knowledge generation rooted in the daily practice of medicine. While companies such as Google and Amazon use dynamic learning systems that learn iteratively through every customer interaction, this efficiency has not materialized on a comparable scale in health systems. An ideal learning health system would learn from every patient interaction to benefit the care for the next patient. Notable advances include the greater use of data generated in the course of clinical care, Common Data Models, and advanced analytics. However, many remaining barriers limit the most effective use of large and growing health care data assets. In this review, we explore the accomplishments, opportunities, and barriers to realizing the learning health system.
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