Related Experiment Video

Updated: Dec 2, 2025

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
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SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

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Advancements in therapeutic drugs targeting of senescence

Mingsheng Zhu1, Ping Meng2, Xian Ling1

  • 1State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Therapeutic Advances in Chronic Disease
|November 2, 2020
PubMed

Insights

Cellular senescence drives aging and related diseases. This review explores drugs like senolytics and SASP inhibitors that target senescent cells to promote healthy aging and treat age-related disorders.

Area of Science:

  • Gerontology
  • Cellular Biology
  • Pharmacology

Background:

  • Aging imposes significant medical and economic burdens.
  • Cellular senescence is a key driver of aging and age-related diseases.
  • Targeting senescent cells shows therapeutic promise.

Purpose of the Study:

  • To review drugs that promote healthy aging by targeting cellular senescence.
  • To update on the therapeutic potential of senolytics, SASP inhibitors, and nutrient signaling regulators.
  • To synthesize recent advancements and clinical implications of these drugs.

Main Methods:

  • Literature review of recent studies on drugs targeting cellular senescence.
  • Categorization of drugs into senolytics, SASP inhibitors, and nutrient signaling regulators.
  • Analysis of therapeutic merits and clinical implications.

Main Results:

  • Various drugs demonstrate healthy aging effects by targeting cellular senescence.
  • Senolytics, SASP inhibitors, and nutrient signaling regulators are key drug types.
  • These drugs show potential for treating age-related disorders.

Conclusions:

  • Drugs targeting cellular senescence represent a promising therapeutic strategy for healthy aging.
  • Further research is needed to fully understand their clinical applications.
  • Advancements in drug development offer new avenues for managing age-related diseases.
Keywords:
advancementdrughealthy agingsenescencesenolytics

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